It appears as if Whole Foods at the Ink Block in the South End will be open for business starting Friday, January 9th at 10:00 AM. Local chefs will be making appearances the opening weekend including the likes of Joanne Chang-Myers.
Parking is available at the new grocery store and tours are even available this week to get a sneak peek at the newest (and largest) Whole Foods to open in Boston. You can follow them on Twitter for more updates @WFM_SouthEnd. 
